Focusing hospital resources on a single antibiotic-resistant pathogen as a sole approach to infection control is inherently flawed. We applied attributable mortality principles to a basic model of bloodstream infections to outline the argument. Screening for methicillin-resistant Staphylococcus aureus alone made sense in the 1980s, but the ongoing emergence of vancomycin-resistant enterococci and antibiotic-resistant strains of gram-negative rods and Candida species, as well as the recognition of the value of team-based infection control programs, support a population-based approach.