Role for adhesion molecules in the spermatogonial stem cell niche

Dirk G de Rooij; S Repping; Ans M M van Pelt

doi:10.1016/j.stem.2008.10.010

Role for adhesion molecules in the spermatogonial stem cell niche

Cell Stem Cell. 2008 Nov 6;3(5):467-8. doi: 10.1016/j.stem.2008.10.010.

Authors

Dirk G de Rooij¹, S Repping, Ans M M van Pelt

Affiliation

¹ Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands. d.g.derooij@uu.nl

PMID: 18983958
DOI: 10.1016/j.stem.2008.10.010

Abstract

In this issue of Cell Stem Cell, Kanatsu-Shinohara et al. (2008) show that beta1-integrin participates in normal spermatogenesis and is required for spermatogonial stem cell (SSC) homing to the basal membrane niche. The methodology used provides a powerful tool to study the role of other factors in niche-SSC interactions.

Publication types

Introductory Journal Article
Comment

MeSH terms

Animals
Blood-Testis Barrier / physiology
Cell Adhesion / physiology*
Cell Differentiation
Cell Movement
Homeostasis
Integrin beta1 / metabolism*
Male
Mice
Protein Binding
Spermatogenesis / physiology*
Spermatogonia / cytology
Spermatogonia / metabolism*
Stem Cell Niche / cytology*
Stem Cell Niche / physiology
Stem Cell Transplantation
Testis / cytology
Testis / growth & development

Substances

Integrin beta1