Tumor evasion may occur via expression of regulatory molecules: a case for CTLA-4 in melanoma

J Invest Dermatol. 2008 Dec;128(12):2750-2. doi: 10.1038/jid.2008.341.

Abstract

Emerging data that show immune-regulating molecules may be ectopically expressed on human tumors suggest that novel mechanisms may induce tumor-related immune suppression, and support the use of antibodies and small molecules to target those immune-suppressive moities.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • CTLA-4 Antigen
  • Humans
  • Immune System
  • Lymphocyte Activation
  • Melanoma / immunology
  • Melanoma / metabolism*
  • Mice
  • Neoplasm Invasiveness
  • Phenotype
  • Signal Transduction
  • Skin Neoplasms / immunology
  • Skin Neoplasms / metabolism*
  • Wnt Proteins / metabolism

Substances

  • Antigens, CD
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Ctla4 protein, mouse
  • Wnt Proteins