A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation

Yoko Fujita; Ryo Murakami; Yasunori Muramatsu; Shunichi Miyakoshi; Toshio Takatsu

doi:10.1038/ja.2008.72

A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation

J Antibiot (Tokyo). 2008 Sep;61(9):545-9. doi: 10.1038/ja.2008.72.

Authors

Yoko Fujita¹, Ryo Murakami, Yasunori Muramatsu, Shunichi Miyakoshi, Toshio Takatsu

Affiliation

¹ Exploratory Research Laboratories I, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. fujita.yoko.x8@daiichisankyo.co.jp

PMID: 19160521
DOI: 10.1038/ja.2008.72

Abstract

In our screening for translocase I inhibitors, we found the novel nucleoside antibiotic, A-94964 in the culture broth of Streptomyces sp. SANK 60404. The structure of A-94964 was elucidated primarily by various NMR studies, including a 1H-31P HMBC experiment. A-94964 has a unique structure which possesses a nucleoside moiety and an N-acylglucosamine moiety connected via a phosphate.

MeSH terms

Anti-Bacterial Agents / chemistry*
Bacteria / enzymology*
Disaccharides / chemistry*
Magnetic Resonance Spectroscopy
Pyrimidine Nucleotides / chemistry*
Streptomyces / metabolism*
Transferases (Other Substituted Phosphate Groups) / antagonists & inhibitors*

Substances

A 94964
Anti-Bacterial Agents
Disaccharides
Pyrimidine Nucleotides
Transferases (Other Substituted Phosphate Groups)
phospho-N-acetylmuramoyl pentapeptide transferase