Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

Prostaglandins. 1977 Mar;13(3):377-88. doi: 10.1016/0090-6980(77)90018-1.

Abstract

Prostacyclin (PGX) (57)-9-deoxy-6,9alpha-epoxy-delta5-PGF1alpha has been found to be a potent stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.

Publication types

  • Comparative Study

MeSH terms

  • Adenylyl Cyclases / blood*
  • Blood Platelets / enzymology*
  • Cyclic AMP / blood
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Homeostasis / drug effects
  • Humans
  • Microsomes / enzymology
  • Models, Biological
  • Peroxides / pharmacology
  • Platelet Aggregation / drug effects
  • Prostaglandins E / pharmacology
  • Prostaglandins F / pharmacology*

Substances

  • Peroxides
  • Prostaglandins E
  • Prostaglandins F
  • Cyclic AMP
  • Adenylyl Cyclases