Abstract
Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Cold Temperature
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Genes, Fungal
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Mutation
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Phosphotransferases (Phosphate Group Acceptor) / genetics
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Phosphotransferases (Phosphate Group Acceptor) / metabolism
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Phytic Acid / metabolism*
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Ribosomes / metabolism*
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism
Substances
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Nuclear Proteins
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RRS1 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Phytic Acid
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Phosphotransferases (Phosphate Group Acceptor)
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KCS1 protein, S cerevisiae