Human behavior is directly related to the development of various skin disease conditions and to the effectiveness of skin disease treatment regimens. Adherence research studies have demonstrated abysmal adherence to topical treatment of common skin disorders, opening new opportunities for improving skin disease treatment outcomes. The treatment of skin raises unique issues in environmental exposures, psychosocial human interactions, biology, and pharmacology. The resulting human behaviors and the potential to understand and modify those behaviors through behavioral research studies are exciting and promising.