Granulocyte transfusions for pediatric patients and the establishment of national treatment guidelines and donor registry

H Vrielink; B Meijer; E van't Ende; L M Ball; A Brand; J J Zwaginga

doi:10.1016/j.transci.2009.05.016

Granulocyte transfusions for pediatric patients and the establishment of national treatment guidelines and donor registry

Transfus Apher Sci. 2009 Aug;41(1):73-6. doi: 10.1016/j.transci.2009.05.016. Epub 2009 Jun 13.

Authors

H Vrielink¹, B Meijer, E van't Ende, L M Ball, A Brand, J J Zwaginga

Affiliation

¹ Sanquin Blood Bank North West, Plesmalaan 125, 1066 CX Amsterdam, The Netherlands. h.vrielink@sanquin.nl

PMID: 19525147
DOI: 10.1016/j.transci.2009.05.016

Abstract

G-CSF/dexamethasone stimulated donor derived granulocyte transfusion (GTX) has been shown in non-randomized studies to be a useful co-therapy in immune-compromised patients unresponsive to conventional antimicrobial treatments. Reports of GTX are however usually single institution adult experiences. Substantiated pediatric data, other than in neonates, is less common.

MeSH terms

Adult
Child
Granulocytes / transplantation*
Humans
Immunocompromised Host / physiology
Infant, Newborn
Informed Consent
Netherlands
Neutropenia / therapy
Patient Selection
Practice Guidelines as Topic
Registries