Abstract
Plants containing pyrrolizidine alkaloids were widely used in traditional medicine. Its hepatotoxicity is main toxicity as well known internationally. In order to providing some foundation for the future studies, the advancement on the pharmacologic actions, toxicity, and pharmacokinetics or toxicokinetics of pyrrolizidine alkaloids was reviewed.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Drug-Related Side Effects and Adverse Reactions
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Humans
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Liver / drug effects*
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Plant Extracts / pharmacokinetics
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Plant Extracts / pharmacology
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Plant Extracts / toxicity
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Plants, Medicinal / chemistry*
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Pyrrolizidine Alkaloids / pharmacokinetics*
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Pyrrolizidine Alkaloids / pharmacology
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Pyrrolizidine Alkaloids / toxicity*
Substances
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Plant Extracts
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Pyrrolizidine Alkaloids