Abstract
We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Epitopes, T-Lymphocyte / immunology*
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HIV Infections / immunology*
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HIV-1 / immunology*
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HIV-1 / physiology
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Humans
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Protein Biosynthesis*
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T-Lymphocytes / immunology*
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Virus Replication*
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rev Gene Products, Human Immunodeficiency Virus / immunology
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tat Gene Products, Human Immunodeficiency Virus / immunology
Substances
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Epitopes, T-Lymphocyte
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rev Gene Products, Human Immunodeficiency Virus
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tat Gene Products, Human Immunodeficiency Virus