[New faces of acute rejection in 2008]

Abstract

Along the time, the definition of acute rejection has been modified according to the successive Banff classifications, the use of C4d and the identification of anti- HLA antibodies. Both cellular and humoral acute rejection are nowadays considered to be different with regard to definition, pathogenesis and hence treatment. The Banffclassification remains a very useful tool to improve the precision of these definitions. The new technologies such as microarrays should help to identify new aspects of acute rejection.