Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

Luigi D'Argenzio; Giacomo Koch; Roberta Bombardieri; Francesco Mori; Romina Moavero; Diego Centonze; Paolo Curatolo

doi:10.1016/j.eplepsyres.2009.07.009

Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

Epilepsy Res. 2009 Nov;87(1):102-5. doi: 10.1016/j.eplepsyres.2009.07.009. Epub 2009 Aug 26.

Authors

Luigi D'Argenzio¹, Giacomo Koch, Roberta Bombardieri, Francesco Mori, Romina Moavero, Diego Centonze, Paolo Curatolo

Affiliation

¹ Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy. luigi.d.argenzio@uniroma2.it

PMID: 19713078
DOI: 10.1016/j.eplepsyres.2009.07.009

Abstract

Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.

MeSH terms

Adolescent
Adult
Analysis of Variance
Brain Mapping
Electric Stimulation
Electromyography
Evoked Potentials, Motor / physiology*
Female
Humans
Male
Middle Aged
Motor Cortex / physiopathology*
Neural Pathways / physiopathology
Parietal Lobe / physiopathology*
Signal Processing, Computer-Assisted
Transcranial Magnetic Stimulation
Tuberous Sclerosis / physiopathology*