The present study aimed at comparing the anthropometric profile of Asian Indian adolescents from Guadeloupe with that of their island counterparts. A total of 720 voluntary 11- to 17-year-old students participated: 180 Asian Indians and 540 age- and sex-matched students of other origin. Weight and height were measured to calculate the BMI. Waist and hip circumferences and bicipital, tricipital, subscapular and supra-iliac skinfold thicknesses were assessed. The percentage of body fat was estimated by bioelectrical impedance analysis. Obesity was defined from BMI according to the International Obesity Task Force recommendations. Asian Indians were smaller and lighter than their counterparts. They had a higher body fat percentage even after adjustment on BMI but the prevalence of obesity did not differ, with an overall prevalence of 5.69 (95 % CI 5.67, 5.71) %. No principal effects of ethnicity on waist and hip circumferences or the waist:hip ratio were evidenced. The sum of the four skinfold thicknesses was the strongest predictor of body fat percentage, and the adjustment of overall body fat on subcutaneous fat cancelled the effect of ethnicity on this dependent variable. The present study found that Asian Indian adolescents from Guadeloupe had the same tendency toward higher body fat and body fat-for-BMI as previously documented in Asian Indian adults. It raises the hypothesis of a higher cardiovascular risk in this ethnic group from adolescence and questions the validity of using common BMI references for screening obesity in multiethnic communities.