Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1

Peter D Kwong; John R Mascola; Gary J Nabel

doi:10.1016/j.chom.2009.09.008

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1

Cell Host Microbe. 2009 Oct 22;6(4):292-4. doi: 10.1016/j.chom.2009.09.008.

Authors

Peter D Kwong¹, John R Mascola, Gary J Nabel

Affiliation

¹ Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

MeSH terms

Antibodies, Monoclonal / immunology*
Antibodies, Monoclonal / isolation & purification
Antibodies, Neutralizing / immunology*
Antibodies, Neutralizing / isolation & purification
B-Lymphocytes / immunology*
HIV Antibodies / immunology*
HIV Antibodies / isolation & purification
HIV-1 / immunology*
Humans
Models, Biological

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
HIV Antibodies

Abstract

MeSH terms

Substances

Grants and funding