Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China

Honglin Chen; Chung Lam Cheung; Hung Tai; Pengxi Zhao; Jasper F W Chan; Vincent C C Cheng; Kwok Hung Chan; Kwok Yung Yuen

doi:10.3201/eid1512.091057

Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China

Emerg Infect Dis. 2009 Dec;15(12):1970-2. doi: 10.3201/eid1512.091057.

Authors

Honglin Chen¹, Chung Lam Cheung, Hung Tai, Pengxi Zhao, Jasper F W Chan, Vincent C C Cheng, Kwok Hung Chan, Kwok Yung Yuen

Affiliation

¹ The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Abstract

Resistance to oseltamivir was observed in influenza A pandemic (H1N1) 2009 virus isolated from an untreated person in Hong Kong, China. Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occurring NA 274Y mutation in this virus is necessary.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antiviral Agents / pharmacology*
Drug Resistance, Viral
Female
Hong Kong
Humans
Influenza A Virus, H1N1 Subtype / drug effects*
Mutation
Neuraminidase / antagonists & inhibitors*
Neuraminidase / genetics
Oseltamivir / pharmacology*

Substances

Antiviral Agents
Oseltamivir
Neuraminidase