Granulocyte transfusion therapy: randomization after all?

Haematologica. 2009 Dec;94(12):1644-8. doi: 10.3324/haematol.2009.013680.

Abstract

Granulocyte transfusions were first used to treat infections in neutropenic patients in the early 1960s. The first donors were patients with chronic myeloid leukemia. Forty years later the value of these transfusions remains unclear. In this perspective article Drs. Drewniak and Kuijpers discuss the relevant data. See related paper on page 1661.

Publication types

  • Comment
  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Aplastic / mortality
  • Anemia, Aplastic / therapy
  • Bacterial Infections / etiology
  • Clinical Trials, Phase III as Topic
  • Granulocytes / cytology
  • Granulocytes / transplantation*
  • Humans
  • Leukocyte Transfusion / adverse effects
  • Leukocyte Transfusion / methods*
  • Mycoses / etiology
  • Randomized Controlled Trials as Topic
  • Survival Analysis
  • Survival Rate