We report on a 64-year-old African-American female with a past medical history of an endometrial adenocarcinoma with metastasis to the right atrium. To our knowledge, there have been only four case reports on endometrial carcinoma metastasizing to the right atrium. In our patient, a percutaneous biopsy under fluoroscopic and transthoracic echocardiographic guidance was performed. Histopathologic evaluation of the specimens revealed an adenocarcinoma, consistent with the patient's history of endometrial carcinoma. This report provides a brief review of diagnosis and treatment of cardiac masses.