Acute encephalopathy associated with influenza A infection in adults

Emerg Infect Dis. 2010 Jan;16(1):139-42. doi: 10.3201/eid1601.090007.

Abstract

We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cytokines / physiology
  • Encephalitis, Viral / complications
  • Encephalitis, Viral / virology*
  • Female
  • Humans
  • Influenza A virus*
  • Influenza, Human / complications
  • Influenza, Human / virology*
  • Male

Substances

  • Cytokines