Abstract
Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP.
(c) 2010 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
CCAAT-Enhancer-Binding Protein-alpha / metabolism
-
CCAAT-Enhancer-Binding Protein-beta / metabolism
-
Cation Transport Proteins / metabolism
-
Cell Line, Tumor
-
Ceruloplasmin / metabolism
-
Estrogen Receptor beta / metabolism
-
Genistein / pharmacology*
-
Humans
-
Iron / metabolism*
-
Male
-
Neuroglia / drug effects*
-
Neuroglia / metabolism*
-
Phytoestrogens / pharmacology*
-
Up-Regulation / drug effects
-
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
-
p38 Mitogen-Activated Protein Kinases / metabolism
Substances
-
CCAAT-Enhancer-Binding Protein-alpha
-
CCAAT-Enhancer-Binding Protein-beta
-
Cation Transport Proteins
-
Estrogen Receptor beta
-
Phytoestrogens
-
metal transporting protein 1
-
Genistein
-
Iron
-
Ceruloplasmin
-
p38 Mitogen-Activated Protein Kinases