Extensive mammalian ancestry of pandemic (H1N1) 2009 virus

Emerg Infect Dis. 2010 Feb;16(2):314-7. doi: 10.3201/eid1602.091141.

Abstract

We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus-like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir. The biological properties of these viruses are consistent with those of their phylogenetic progenitors, indicating longstanding adaptation to mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Disease Outbreaks*
  • Disease Reservoirs / virology*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics*
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / physiology
  • Mammals / virology*
  • Phylogeny
  • Quail / virology
  • Swine
  • Swine Diseases / virology*
  • Virus Replication / genetics*

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus