Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link

Sara Toffanin; Scott L Friedman; Josep M Llovet

doi:10.1016/j.ccr.2010.01.018

Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link

Cancer Cell. 2010 Feb 17;17(2):115-7. doi: 10.1016/j.ccr.2010.01.018.

Authors

Sara Toffanin¹, Scott L Friedman, Josep M Llovet

Affiliation

¹ Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA; Department of Experimental Oncology and Gastrointestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.

PMID: 20159605
DOI: 10.1016/j.ccr.2010.01.018

Abstract

There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.