Abstract
Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.
Copyright 2010 Mosby, Inc. All rights reserved.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Ataxia Telangiectasia / blood*
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Ataxia Telangiectasia / immunology
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Biomarkers / blood
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C-Reactive Protein / metabolism
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CD4-CD8 Ratio
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Child
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Child, Preschool
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Cross-Sectional Studies
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Disease Progression
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Female
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Follow-Up Studies
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Humans
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Immunoassay
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Interleukin-8 / blood*
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Male
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Middle Aged
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Phenotype
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Prognosis
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Retrospective Studies
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Young Adult
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alpha-Fetoproteins / metabolism
Substances
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Biomarkers
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Interleukin-8
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alpha-Fetoproteins
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C-Reactive Protein