Elevated serum IL-8 levels in ataxia telangiectasia

J Pediatr. 2010 Apr;156(4):682-4.e1. doi: 10.1016/j.jpeds.2009.12.007. Epub 2010 Feb 20.

Abstract

Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Ataxia Telangiectasia / blood*
  • Ataxia Telangiectasia / immunology
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • CD4-CD8 Ratio
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoassay
  • Interleukin-8 / blood*
  • Male
  • Middle Aged
  • Phenotype
  • Prognosis
  • Retrospective Studies
  • Young Adult
  • alpha-Fetoproteins / metabolism

Substances

  • Biomarkers
  • Interleukin-8
  • alpha-Fetoproteins
  • C-Reactive Protein