A comparative study of the serological response to Japanese encephalitis vaccine in HIV-infected and uninfected Thai children

Vaccine. 2010 Apr 30;28(20):3563-6. doi: 10.1016/j.vaccine.2010.02.108. Epub 2010 Mar 11.

Abstract

We report a prospective study of mouse brain derived inactivated Japanese encephalitis (JE) vaccine, given in 3-dose EPI program to human immune deficiency virus (HIV)-exposed Thai infants. 18 HIV-infected receiving antiretroviral therapy with median baseline CD4 of 33.1%, and 92 HIV-uninfected children were studied. All but one HIV-infected child seroconverted after the second dose. The geometric mean titers (GMTs) 3 months after the second and third doses in HIV-infected vs HIV-uninfected children were 247 vs 938 (p=0.022), and 2273 vs 24069 (p=0.009), respectively. Urticaria or angioedema found in 4% and 6% in HIV-infected and -uninfected children, respectively (p=1.0). The vaccine was safe and immunogenic but antibody response in HIV-infected children was not as high as in uninfected children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Antibodies, Viral / immunology
  • Antibody Formation
  • Child, Preschool
  • Encephalitis, Japanese / immunology
  • Encephalitis, Japanese / prevention & control*
  • Female
  • HIV Infections / immunology
  • HIV Infections / virology*
  • Humans
  • Immunization, Secondary
  • Infant
  • Japanese Encephalitis Vaccines / administration & dosage
  • Japanese Encephalitis Vaccines / immunology*
  • Male
  • Prospective Studies
  • Thailand

Substances

  • Antibodies, Viral
  • Japanese Encephalitis Vaccines