Transferring death: a role for tRNA in apoptosis regulation

Mol Cell. 2010 Mar 12;37(5):591-2. doi: 10.1016/j.molcel.2010.02.001.

Abstract

Cytochrome c from mitochondria significantly accelerates the apoptotic process. In this issue of Molecular Cell, Mei et al. show that cytochrome c is itself regulated by binding to tRNA, providing an unanticipated level of control of cell fate decisions.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis* / drug effects
  • Apoptotic Protease-Activating Factor 1 / metabolism
  • Caspase 3 / metabolism
  • Caspase 9 / metabolism
  • Caspase Inhibitors
  • Cell Survival
  • Cytochromes c / metabolism
  • Cytosol / enzymology
  • Doxorubicin / pharmacology
  • Enzyme Activation
  • Humans
  • Mitochondria / enzymology
  • Protein Binding
  • RNA, Transfer / metabolism*
  • Ribonucleases / metabolism

Substances

  • APAF1 protein, human
  • Apoptotic Protease-Activating Factor 1
  • Caspase Inhibitors
  • Doxorubicin
  • Cytochromes c
  • RNA, Transfer
  • Ribonucleases
  • CASP3 protein, human
  • CASP9 protein, human
  • Caspase 3
  • Caspase 9
  • ranpirnase