Fatal vancomycin- and linezolid-resistant Enterococcus faecium sepsis in a child undergoing allogeneic haematopoietic stem cell transplantation for beta-thalassaemia major

J Med Microbiol. 2010 Jul;59(Pt 7):839-842. doi: 10.1099/jmm.0.018598-0. Epub 2010 Mar 18.

Abstract

Recently vancomycin-resistant and sporadically linezolid-resistant Enterococcus species have been described in adults. We report what we believe to be the first case of a child with prolonged bone marrow aplasia following haematopoietic stem cell transplantation developing a fatal sepsis caused by Enterococcus faecium resistant to glycopeptides and linezolid.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Drug Resistance, Multiple, Bacterial*
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / isolation & purification
  • Fatal Outcome
  • Female
  • Gram-Positive Bacterial Infections / microbiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Sepsis / microbiology
  • beta-Thalassemia / therapy*

Substances

  • Anti-Bacterial Agents