Clinical importance of vitamin D receptor gene polymorphism in invasive ductal carcinoma

Int Surg. 2009 Oct-Dec;94(4):304-9.

Abstract

In this study, we aimed to investigate the clinical importance of the vitamin D receptor gene polymorphism in invasive ductal breast cancer. All patients included in the study had clinical T1-2, N0-M0 invasive ductal carcinoma. Patients' demographics, axillary metastasis status, metastatic lymph nodi/total dissected lymph nodes from axilla, histopathologic characteristics of tumors, local recurrences, and survival ratio were assessed. Vitamin D receptor B genotype frequencies in the patient group (P > 0.05) were as follows: B/b, 43 (77%); B/B, 13 (23%). In conclusion, the vitamin D receptor gene B allele does not seem to be related to local recurrence and distant metastasis of invasive ductal cancer of the breast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • Carcinoma, Ductal, Breast / genetics*
  • Diagnostic Imaging
  • Female
  • Genotype
  • Humans
  • Lymph Node Excision
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Invasiveness / genetics
  • Neoplasm Metastasis / genetics
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Staging
  • Polymorphism, Genetic*
  • Receptors, Calcitriol / genetics*
  • Retrospective Studies
  • Statistics, Nonparametric
  • Survival Rate

Substances

  • Receptors, Calcitriol