Abstract
Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / metabolism
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Candida albicans / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Clotrimazole / pharmacology
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Drug Synergism
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Fermentation
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Pyrrolidinones / chemistry
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Pyrrolidinones / isolation & purification
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Pyrrolidinones / pharmacology
Substances
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Antifungal Agents
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Pyrrolidinones
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synerazol
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Clotrimazole