High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China

Clin Infect Dis. 2010 Jul 15;51(2):189-94. doi: 10.1086/653535.

Abstract

The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to resolution of fever.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • China
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Female
  • Genes, rRNA / genetics
  • Humans
  • Macrolides / pharmacology*
  • Macrolides / therapeutic use
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mycoplasma pneumoniae / drug effects*
  • Mycoplasma pneumoniae / isolation & purification
  • Pneumonia, Mycoplasma / microbiology*
  • Point Mutation
  • RNA, Ribosomal, 23S / genetics
  • Sequence Analysis, DNA
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Macrolides
  • RNA, Ribosomal, 23S

Associated data

  • GENBANK/HM043729
  • GENBANK/HM043730
  • GENBANK/HM043731