Fragrance material review on 3,5,5-trimethyl-1-hexanol

Food Chem Toxicol. 2010 Jul:48 Suppl 4:S47-50. doi: 10.1016/j.fct.2010.05.026.

Abstract

A toxicologic and dermatologic review of 3,5,5-trimethyl-1-hexanol when used as a fragrance ingredient is presented. 3,5,5-Trimethyl-1-hexanol is a member of the fragrance structural group branched chain saturated alcohols. The common characteristic structural elements of the alcohols with saturated branched chain are one hydroxyl group per molecule, and a C(4) to C(12) carbon chain with one or several methyl side chains. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. A safety assessment of the entire branched chain saturated alcohol group will be published simultaneously with this document; please refer to Belsito et al. (2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dermatitis, Allergic Contact
  • Dermatitis, Phototoxic
  • Eye Injuries / chemically induced
  • Hexanols / chemistry*
  • Hexanols / toxicity*
  • Humans
  • Perfume / chemistry*
  • Perfume / toxicity*

Substances

  • Hexanols
  • Perfume
  • 3,5,5-trimethyl-1-hexanol