Neonatal alloimmune neutropenia due to immunoglobulin G antibodies against human neutrophil antigen-5a

Transfusion. 2011 Mar;51(3):574-7. doi: 10.1111/j.1537-2995.2010.02858.x. Epub 2010 Aug 23.

Abstract

Background: Neonatal alloimmune-mediated neutropenia (NAIN) due to maternal alloantibodies directed against one of the human neutrophil antigens (HNAs) can cause severe infections. NAIN has been described as caused by antibodies against HNA-1a, -b, -c, -2a, -3a, or -4a, but not by antibodies against HNA-5a.

Results: Blood from a 3-week-old newborn and from his parents was sent to our laboratory because of suspicion of NAIN. Granulocyte-specific antibodies were present in the maternal antiserum and reactive with the paternal granulocytes. The specificity of the maternal alloantibodies was shown to be anti-HNA-5a by the monoclonal antibody immobilization of granulocyte antigens assay. The mother was genotyped HNA-5a negative, and the father was genotyped homozygous HNA-5a positive.

Conclusion: We identified a first case of NAIN due to maternal alloantibodies against HNA-5a.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibody Specificity
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Infant, Newborn
  • Isoantibodies / blood*
  • Isoantigens / immunology*
  • Male
  • Neutropenia / etiology*
  • Neutrophils / immunology*
  • Pregnancy

Substances

  • 5a antigen
  • Immunoglobulin G
  • Isoantibodies
  • Isoantigens