Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours

Emerg Infect Dis. 2010 Oct;16(10):1633-6. doi: 10.3201/eid1610.100688.

Abstract

An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient's exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiviral Agents / pharmacology*
  • Drug Resistance, Viral / genetics*
  • Evolution, Molecular
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza A Virus, H1N1 Subtype / pathogenicity
  • Influenza, Human / drug therapy*
  • Influenza, Human / epidemiology
  • Influenza, Human / virology
  • Mutation*
  • Oseltamivir / pharmacology*
  • Pandemics
  • Phylogeny
  • Sequence Analysis, DNA / methods
  • Time Factors

Substances

  • Antiviral Agents
  • Oseltamivir