Abstract
The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. Immunotherapeutic treatment using a cocktail of antigens has been proposed as a "universal" vaccine strategy. We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray. Expression of tumor antigens p53, SP17, survivin, WT1, and NY-ESO-1 was observed in 120 (48.0%), 173 (68.9%), 208 (90.0%), 129 (56.3%), and 27 (11.0%) of 270 tumor specimens, respectively. In 93.2% of EOC, at least one of the investigated tumor antigens was (over)expressed. Expression of MHC class I was observed in 78.1% of EOC. In 3 out 4 primary tumors, (over)expression of a tumor antigen combined with MHC class I was observed. These results indicate that a multiepitope vaccine, comprising these antigens, could serve as a universal therapeutic vaccine for the vast majority of ovarian cancer patients.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antigens, Neoplasm / genetics
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Antigens, Neoplasm / immunology*
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Antigens, Neoplasm / metabolism*
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Antigens, Surface / immunology
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Antigens, Surface / metabolism
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Calmodulin-Binding Proteins
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Cancer Vaccines / immunology*
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Carrier Proteins / immunology
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Carrier Proteins / metabolism
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Female
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Histocompatibility Antigens Class I / metabolism*
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Humans
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Immunotherapy
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Inhibitor of Apoptosis Proteins
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Membrane Proteins / immunology
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Membrane Proteins / metabolism
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Microarray Analysis
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Microtubule-Associated Proteins / immunology
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Microtubule-Associated Proteins / metabolism
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Middle Aged
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Ovarian Neoplasms / immunology*
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Ovarian Neoplasms / prevention & control
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Survivin
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Tumor Suppressor Protein p53 / immunology
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Tumor Suppressor Protein p53 / metabolism
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WT1 Proteins / immunology
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WT1 Proteins / metabolism
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Young Adult
Substances
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Antigens, Neoplasm
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Antigens, Surface
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BIRC5 protein, human
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CTAG1B protein, human
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Calmodulin-Binding Proteins
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Cancer Vaccines
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Carrier Proteins
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Histocompatibility Antigens Class I
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Inhibitor of Apoptosis Proteins
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Membrane Proteins
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Microtubule-Associated Proteins
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SPA17 protein, human
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Survivin
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Tumor Suppressor Protein p53
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WT1 Proteins