Neuromyelitis optica-IgG+ optic neuritis associated with celiac disease and dysgammaglobulinemia: a role for tacrolimus?

Eur J Paediatr Neurol. 2011 May;15(3):265-7. doi: 10.1016/j.ejpn.2010.09.005. Epub 2010 Nov 12.

Abstract

We present a pediatric case of recurrent optic neuritis, celiac disease, partial IgA and IgG3 deficiency in the context of anti-aquaporin-4 auto-immunity and familial IgA deficiency with celiac disease. Treatment with tacrolimus was successful in preventing disease relapses. This case stresses the relevance of central nervous system anti-aquaporin-4 auto-immunity in a broader context of immune dysregulation and neuro-immunology.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / biosynthesis*
  • Autoantibodies / blood
  • Celiac Disease / complications
  • Celiac Disease / drug therapy
  • Celiac Disease / immunology*
  • Child
  • Dysgammaglobulinemia / complications
  • Dysgammaglobulinemia / drug therapy
  • Dysgammaglobulinemia / immunology*
  • Female
  • Humans
  • Immunoglobulin G / biosynthesis*
  • Immunoglobulin G / blood
  • Immunosuppressive Agents / administration & dosage
  • Neuromyelitis Optica / complications
  • Neuromyelitis Optica / drug therapy
  • Neuromyelitis Optica / immunology*
  • Optic Neuritis / complications
  • Optic Neuritis / drug therapy
  • Optic Neuritis / immunology*
  • Tacrolimus / administration & dosage*

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Tacrolimus