Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome

Pediatr Infect Dis J. 2011 Apr;30(4):357-9. doi: 10.1097/INF.0b013e3181ff85a8.

Abstract

Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Antibody Affinity*
  • B-Lymphocytes / immunology
  • Child
  • Child, Preschool
  • Down Syndrome*
  • Humans
  • Immunization, Secondary*
  • Tetanus Toxoid / administration & dosage
  • Tetanus Toxoid / immunology*

Substances

  • Antibodies, Bacterial
  • Tetanus Toxoid