Mixtures of oseltamivir-sensitive and -resistant pandemic influenza A/H1N1/2009 viruses in immunocompromised hospitalized children

Pediatr Infect Dis J. 2011 Jul;30(7):625-7. doi: 10.1097/INF.0b013e31820929ab.

Abstract

We report on 3 immunocompromised children infected with pandemic influenza A/H1N1/2009 in whom mixtures of oseltamivir-susceptible and oseltamivir-resistant viral populations developed, despite them receiving relatively short-term courses of oseltamivir. In addition, it was found that bacterial coinfections were common, indicating that empiric, antibiotics should be considered in such patients when infected with influenza virus.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / administration & dosage
  • Antiviral Agents / pharmacology*
  • Bacterial Infections / epidemiology
  • Child
  • Child, Hospitalized
  • Child, Preschool
  • Drug Resistance, Viral*
  • Genetic Variation*
  • Humans
  • Immunocompromised Host
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / complications
  • Influenza, Human / drug therapy
  • Influenza, Human / virology*
  • Male
  • Oseltamivir / administration & dosage
  • Oseltamivir / pharmacology*

Substances

  • Antiviral Agents
  • Oseltamivir