Abstract
The mechanisms limiting clonal T-cell expansion in response to cytokines to cells that have recognised cognate antigen via their T-cell receptor are incompletely understood. A study by Rawlings et al identifies one such mechanism that functions, unexpectedly, through chromatin compaction and involves a subunit of condensin — a complex better known for restructuring chromosomes in mitosis.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / metabolism*
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Cell Proliferation
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Chromatin Assembly and Disassembly / physiology*
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DNA-Binding Proteins / metabolism*
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Gene Expression Regulation / immunology*
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Immunity, Cellular / immunology*
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Interleukin-2 / metabolism
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Lymphocyte Activation / immunology*
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Multiprotein Complexes / metabolism*
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Receptors, Antigen, T-Cell / metabolism
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STAT5 Transcription Factor / metabolism
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T-Lymphocyte Subsets / cytology*
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T-Lymphocyte Subsets / immunology
Substances
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DNA-Binding Proteins
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Interleukin-2
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Multiprotein Complexes
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Receptors, Antigen, T-Cell
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STAT5 Transcription Factor
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condensin complexes
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Adenosine Triphosphatases