Plexiform fibrohistiocytic tumor with molecular and cytogenetic analysis

Pediatr Dermatol. 2011 Jan-Feb;28(1):26-9. doi: 10.1111/j.1525-1470.2010.01370.x. Epub 2011 Jan 25.

Abstract

A child with plexiform fibrohistiocytic tumor is presented, in whom a superficial biopsy was misdiagnosed as an inflammatory granuloma. Cytogenetic analysis revealed a 46,X,del(X)(q13)[3]/46,XX[23] karyotype. However, fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (CGH) analysis failed to detect any numerical or quantitative genomic anomaly. Because of lack of specific chromosomal hallmarks, a molecular diagnosis of plexiform fibrohistiocytic tumor with the currently available tools is not reliable.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antigens, CD / analysis
  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / analysis
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • Chromosome Deletion
  • Cytogenetic Analysis / methods
  • Diagnostic Errors
  • Female
  • Granuloma / diagnosis
  • Histiocytoma, Malignant Fibrous / diagnosis*
  • Histiocytoma, Malignant Fibrous / genetics
  • Histiocytoma, Malignant Fibrous / surgery
  • Humans
  • Sensitivity and Specificity
  • Sex Chromosome Disorders / genetics
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / surgery
  • Treatment Outcome

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human