Emergence of daptomycin-resistant VRE: experience of a single institution

Infect Control Hosp Epidemiol. 2011 Apr;32(4):391-4. doi: 10.1086/659152.

Abstract

Recent surveillance from US hospitals shows that more than 99.5% of vancomycin-resistant enterococci (VRE) isolates remain susceptible to daptomycin. This report describes emergence of daptomycin-resistant VRE at a major cancer center. The percentage of patients with daptomycin-resistant VRE bacteremia increased from 3.4% in 2007 to 15.2% in 2009 ([Formula: see text]). Without susceptibility data, empiric daptomycin therapy for VRE infections should be used with caution.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / complications
  • Bacteremia / drug therapy
  • Child
  • Daptomycin / therapeutic use*
  • Drug Resistance, Multiple, Bacterial*
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / isolation & purification
  • Female
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / drug therapy*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Neoplasms / complications
  • Vancomycin Resistance

Substances

  • Anti-Bacterial Agents
  • Daptomycin