Abstract
A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Protozoan / immunology
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Antigens, Protozoan / immunology
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Apicomplexa / immunology
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Apicomplexa / isolation & purification
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CD4 Antigens / analysis*
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Clone Cells / immunology
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Clone Cells / metabolism
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Clone Cells / physiology
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Female
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Immunity, Cellular / immunology
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Immunity, Cellular / physiology
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Interferon-gamma / metabolism
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Interleukin-2 / metabolism
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Malaria / immunology
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Malaria / parasitology
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Malaria / prevention & control*
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Mice
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Mice, Inbred BALB C
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Plasmodium berghei / immunology
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Plasmodium berghei / isolation & purification
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Spleen / cytology
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Spleen / parasitology
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T-Lymphocytes, Cytotoxic / immunology
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T-Lymphocytes, Cytotoxic / metabolism
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T-Lymphocytes, Cytotoxic / physiology*
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T-Lymphocytes, Helper-Inducer / immunology
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T-Lymphocytes, Helper-Inducer / metabolism
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T-Lymphocytes, Helper-Inducer / physiology*
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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CD4 Antigens
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Interleukin-2
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Interferon-gamma