Expression of the human V beta 8 gene product preferentially correlates with class II major histocompatibility complex restriction specificity

L Imberti; A Sottini; G Spagnoli; D Primi

doi:10.1002/eji.1830201244

Expression of the human V beta 8 gene product preferentially correlates with class II major histocompatibility complex restriction specificity

Eur J Immunol. 1990 Dec;20(12):2817-9. doi: 10.1002/eji.1830201244.

Authors

L Imberti¹, A Sottini, G Spagnoli, D Primi

Affiliation

¹ Consorzio per le Biotecnologie, Laboratorio di Biotecnologie, Brescia, Italy.

PMID: 2148526
DOI: 10.1002/eji.1830201244

Abstract

We report that, in peripheral blood T cells, the V beta 8 gene product is much more represented on CD4+CD8- than on CD4-CD8+ lymphocytes. This skewing was observed in all individuals tested and with two independent strategies, one of which allows the selection of V beta 8+ T cells independently from their major histocompatibility complex-antigen specificity. Our data imply that the human V beta 8 gene product confers class II restriction specificity and that both the T cell receptor chains and CD4 molecule are involved in the selection of the T cell repertoire.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Expression
HLA-D Antigens / genetics*
Humans
Lymphocyte Activation
Major Histocompatibility Complex*
Receptors, Antigen, T-Cell / genetics*
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets / physiology*

Substances

HLA-D Antigens
Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, alpha-beta