Abstract
Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. Trabectedin is a potential cause of rhabdomyolysis. Herein, we describe a case of rhabdomyolysis in a female patient with recurrent metastatic leiomyosarcoma of the uterus and who had full recovery, and we review the already published cases in order to identify a common pattern of emergence.
MeSH terms
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Aged
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / adverse effects*
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Biomarkers / blood
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Comorbidity
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Creatine Kinase / blood*
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Dioxoles / administration & dosage
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Dioxoles / adverse effects*
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Drug Interactions
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Fatal Outcome
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Female
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Humans
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Leiomyosarcoma / drug therapy*
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Leiomyosarcoma / enzymology
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Leiomyosarcoma / secondary
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Renal Insufficiency / etiology
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Rhabdomyolysis / chemically induced*
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Rhabdomyolysis / complications
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Rhabdomyolysis / enzymology
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Tetrahydroisoquinolines / administration & dosage
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Tetrahydroisoquinolines / adverse effects*
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Trabectedin
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Uterine Neoplasms / drug therapy*
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Uterine Neoplasms / enzymology
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Uterine Neoplasms / pathology
Substances
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Antineoplastic Agents, Alkylating
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Biomarkers
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Dioxoles
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Tetrahydroisoquinolines
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Creatine Kinase
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Trabectedin