Iodolipids have been used as a contrast medium for hepatosplenic computed tomography (CT) in 148 patients. In all but two of these cases, the contrast material was injected by the intravenous route. The method appears to be safe due to the marked reduction of dosage in CT compared with conventional radiographic iodolipid hepatography. This decreased dosage is made possible by the improved density and spatial resolution of CT. Pictorial and histographic densitometric analysis of normal and abnormal liver after iodolipid administration yields considerable diagnostic improvement.