Abstract
To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adolescent
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Antibodies, Viral / blood
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Child
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Child, Preschool
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DNA, Viral / blood*
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DNA, Viral / cerebrospinal fluid*
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DNA, Viral / genetics
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Encephalitis, Viral / epidemiology
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Encephalitis, Viral / virology*
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High-Throughput Nucleotide Sequencing / methods
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Humans
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Immunoglobulin M / blood
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India / epidemiology
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Molecular Sequence Data
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Parvoviridae Infections / epidemiology
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Parvoviridae Infections / virology*
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Parvovirus / classification
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Parvovirus / genetics
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Parvovirus / immunology
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Parvovirus / isolation & purification*
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Phylogeny
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Polymerase Chain Reaction / methods
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Sequence Analysis, DNA
Substances
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Antibodies, Viral
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DNA, Viral
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Immunoglobulin M
Associated data
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GENBANK/HQ593530
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GENBANK/HQ593531
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GENBANK/HQ593532