Abstract
It has become increasingly recognized that nonsteroidal anti-inflammatory drug (NSAID) use is associated with serious gastroduodenal mucosal injury that can eventuate in upper gastrointestinal bleeding or perforation. This article discusses the lack of predictive value of studies administering NSAIDs to normal volunteers. The new data concerning prevention and treatment of chronic NSAID ulcers is also discussed.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthritis / drug therapy
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Duodenoscopy
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Gastroscopy
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Humans
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Peptic Ulcer / chemically induced*
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Peptic Ulcer / complications
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Peptic Ulcer / prevention & control
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Peptic Ulcer / therapy
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Peptic Ulcer Perforation / complications
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Reference Values
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Research Design
Substances
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Anti-Inflammatory Agents, Non-Steroidal