Abstract
The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.
MeSH terms
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Animals
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Ascorbic Acid / pharmacology
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Ascorbic Acid / therapeutic use
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Cholesterol / blood
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Cholesterol, Dietary / pharmacology
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Cholesterol, HDL / blood
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Cholesterol, HDL / drug effects
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Cholesterol, LDL / blood
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Cholesterol, LDL / drug effects
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Hypercholesterolemia / blood
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Hypercholesterolemia / chemically induced
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Hypercholesterolemia / drug therapy*
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Male
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Rabbits
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Simvastatin / pharmacology
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Simvastatin / therapeutic use*
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Triglycerides / blood
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Vitamin A / pharmacology
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Vitamin A / therapeutic use
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Vitamin E / pharmacology
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Vitamin E / therapeutic use
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Vitamins / pharmacology
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Vitamins / therapeutic use*
Substances
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Antioxidants
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Cholesterol, Dietary
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Cholesterol, HDL
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Cholesterol, LDL
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Triglycerides
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Vitamins
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Vitamin A
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Vitamin E
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Cholesterol
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Simvastatin
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Ascorbic Acid