Abstract
To evaluate serologic immunity against clinical infections by heat-labile enterotoxin-producing Escherichia coli (LT-ETEC) in rural Bangladesh, 124 children and adult women with LT-ETEC diarrhea (cases) were compared with 347 age-matched community controls. In paired acute-convalescent sera from the cases, IgG anti-CFA I and anti-CFA II antibody titers increased eight-to ninefold after infection by LT-ETEC with the homologous CFA, and IgG anti-LT antibody titers increased fourfold for all LT-ETEC infections. Anti-CFA and anti-LT titers peaked in controls aged 12-23 months, the age group with the highest incidence of ETEC infections. However, antibody titers were similar in acute sera from cases and in sera from controls. Although serum IgG anti-CFA and anti-LT antibodies rose in response to LT-ETEC infections and paralleled the age-specific incidence of ETEC in the community, these antibodies were not associated with a lower risk of LT-ETEC diarrhea.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Age Factors
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Antibodies, Bacterial / analysis
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Antibodies, Bacterial / biosynthesis*
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Antigens, Bacterial / immunology*
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Bacterial Toxins / biosynthesis
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Bacterial Toxins / immunology*
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Bangladesh / epidemiology
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Case-Control Studies
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Child
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Child, Preschool
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Diarrhea / epidemiology
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Diarrhea / immunology*
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Enterotoxins / biosynthesis
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Enterotoxins / immunology*
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Escherichia coli Infections / epidemiology
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Escherichia coli Infections / immunology*
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Escherichia coli Proteins*
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Female
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Fimbriae Proteins*
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Follow-Up Studies
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Humans
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Immunoglobulin G / analysis
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Immunoglobulin G / biosynthesis
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Infant
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Infant, Newborn
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Male
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Risk Factors
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Rural Population
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Toxins
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Enterotoxins
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Escherichia coli Proteins
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Immunoglobulin G
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colonization factor antigens
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Fimbriae Proteins
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heat-labile enterotoxin, E coli