In two studies we examined the role of two regulatory foci (i.e., prevention and promotion) in predicting Australian's attitudes to different types of migrants. According to regulatory focus theory, promotion-focused self-regulation is concerned with nurturance and accomplishment needs and involves the pursuit of wishes and aspirations. As such, it results in sensitivity to positive outcomes and to relative pleasure from gains. On the other hand, prevention-focused self-regulation is concerned with security needs and is directed at meeting duties and obligations. As such, it results in sensitivity to negative outcome and relative pain from losses. In Study 1, as predicted, the extent of promotion focus (i.e., a concern with accomplishment and the pursuit of ideals) predicted more positive attitudes to culturally similar and economically beneficial migrants, whereas the extent of prevention focus (i.e., concern with security and meeting obligations) predicted more negative attitudes to migrants who are culturally dissimilar. In Study 2 we replicated and extended these findings, showing that the extent of promotion focus and a lack of concern with threats predicted positive attitudes to both culturally similar and economically beneficial migrants, which, in the case of the latter group, was mediated by a focus on the benefits these migrants provide. In the case of culturally dissimilar migrants, the extent of promotion focus and a concern with gains predicted more positive attitudes. However, for economically less beneficial migrants, neither the extent of promotion nor prevention focus was a predictor. Only lower concerns with threat predicted more positive attitudes to this migrant group. The results are discussed with respect to other determinants of attitudes to migrants and the implications for migration and asylum-seeker policy.