Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population

Genet Mol Res. 2011 Oct 31;10(4):4126-32. doi: 10.4238/2011.October.31.12.

Abstract

Accumulation of hydrogen peroxide (H(2)O(2)) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. We found no association between CAT (Asp-389) gene polymorphism and vitiligo susceptibility in Turkish vitiligo patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalase / genetics*
  • Exons*
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Hydrogen Peroxide / metabolism
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide*
  • Turkey / ethnology
  • Vitiligo / ethnology
  • Vitiligo / genetics*

Substances

  • Hydrogen Peroxide
  • Catalase