Modulation of the two promoters of the galactose operon of Escherichia coli

Nature. 1979 Jun 7;279(5713):492-4. doi: 10.1038/279492a0.

Abstract

The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein.

MeSH terms

  • Binding Sites
  • Cyclic AMP / pharmacology
  • DNA-Directed RNA Polymerases / metabolism*
  • Enzyme Induction
  • Escherichia coli / genetics*
  • Galactokinase / genetics
  • Galactose / genetics*
  • Genes, Regulator
  • Operon*
  • Receptors, Cyclic AMP / pharmacology
  • Repressor Proteins / genetics
  • Transcription, Genetic / drug effects

Substances

  • Receptors, Cyclic AMP
  • Repressor Proteins
  • Cyclic AMP
  • Galactokinase
  • DNA-Directed RNA Polymerases
  • Galactose