Abstract
The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ∼65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Colombia
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Family Characteristics
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Female
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Genetic Variation*
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Humans
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Infant
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Latent Tuberculosis / diagnosis*
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Latent Tuberculosis / genetics*
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Latent Tuberculosis / immunology
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Male
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Middle Aged
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Mycobacterium tuberculosis / immunology*
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Tuberculin Test / methods*
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Young Adult